Can I Use Nexgard and Frontline Together?

Can I Use Nexgard and Frontline Together
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Medications should generally not be combined unless specifically advised to do so by a medical professional. NexGard and Frontline can be used safely in certain cases, but you are only recommended to combine treatments if directly advised to do so by your veterinarian.

Combining tick and flea treatments can lead to an overdose threatening the life of your beloved pet. We'll be taking you through a closer look at what each treatment does so that you understand why using NexGard and Frontline together is not a good idea.

Why Avoid Combining Treatments?

Both NexGard and Frontline Plus are products that are designed to eliminate ticks and fleas completely without the need for any supplemental chemicals or treatments.

If a single course doesn't sort out the infestation, then you'll need to consult a vet to find something that spans the entire lifecycle of these dreaded parasites.

Combing NexGard and Frontline won't help much more than using a single application. It is not worth the risk. You should never combine oral and topical tick and flea treatments regardless of which brands or chemical composition you're considering.

Tick and Flea Treatments That You Can Try

The only two oral flea treatments that you can combine with NexGard or Frontline products is Capstar or Comfortis.

Capstar is available over the counter and works well to clear out the whole flea colony, including adults and eggs. Comfortis needs a prescription and is a stronger treatment that lasts for a month, but in this case, you'll have the insight of your vet at your disposal before combining.

Can I Use Nexgard and Frontline Together

NexGard vs. Frontline

Each treatment uses a different chemical compound structure to destroy fleas at every stage of their lifecycle. It is crucial to keep in mind that even though both work, infestations can reoccur if any latent larvae are left in the immediate environment, and a course of treatment is not repeated.


NexGard arrives as a chewable tablet containing the chemical Afoxolaner. This compound is an efficient flea and tick killer, working at every stage of a flea's life, including adulthood. The treatment gets rid of all ticks and fleas within the first 24-hours of administration, but this doesn't stop new infestations from arising.


Frontline takes a different approach to tick and flea management. It's a product that is preferred by many, thanks to its longstanding record for speed and efficacy.

Instead of Afoxolaner, Frontline uses Fipronil and Methoprene. You apply it to the skin, and it goes to work within 12 hours. Once active, Frontline kills ticks and fleas for a further 48 hours. As the more expensive product, it's considered to be more effective than NexGard.

Assessing the Risk of Overdose

The danger of an overdose lies with a dog's inability to metabolize vast quantities of the active chemicals in each treatment. NexGard alone can result in an overdose if the dosage is exceeded by five times the recommended quantity relative to the dog's body weight.

When crossing over to Fipronil and Methoprene, studies have shown that all animals tolerate it much better. Mortality only occurs at extremely high concentrations. Combining substances makes the body work harder to expel any arising toxins, which lower the threshold for an overdose.

Look for Side Effects

If you're already using a combination,  stop and stick to one treatment only. Always watch for side effects regardless of which solution you're using. Hair loss, redness, dryness, itchiness, or any type of irritation is not normal.

There shouldn't be any flaking of the skin, no loss of oil in your dog's coat. Pay attention to the health of their skin as a first indicator that the tick and flea treatment you've chosen is not working. Side effects may not be evident right away.

For example, NexGard's side effects only manifest after a full month, so they'll only start showing through the second course of treatment. Stay vigilant.

When to See a Vet

Keeping your dog on a good preventative treatment such as either NexGard or Frontline should always be enough to keep ticks and fleas at bay.

If either does not work, consult a vet before resorting to a concoction of home remedies and over-the-counter combinations. Yes, there are natural methods that help eliminate fleas in the environment, but eventually, this shouldn't be a problem.

After three months and you're still battling fleas, you've probably got another issue and need to see a vet. Almost all infections are relatively easy to clear. Once you've found a solution, you've got a lasting fix to living free from ticks and fleas.

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